Flights from Madrid to Brussels

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Cheap one-way flights

If you're planning to travel one-way to Brussels, find the best flight deals available here.
Air Europa
DEPARTURE
MAD - BRU
Sat. Oct 10, 2026
Price per a person from
$335
Air Europa
DEPARTURE
MAD - BRU
Sun. Oct 11, 2026
Price per a person from
$360
Brussels Airlines
DEPARTURE
MAD - BRU
Sun. Oct 11, 2026
Price per a person from
$393
Iberia
DEPARTURE
MAD - BRU
Sat. Oct 10, 2026
Price per a person from
$434
Tap Air Portugal
DEPARTURE
MAD - BRU
Sun. Oct 11, 2026
Price per a person from
$441
Iberia
DEPARTURE
MAD - BRU
Sun. Oct 11, 2026
Price per a person from
$491
Tap Air Portugal
DEPARTURE
MAD - BRU
Sat. Oct 10, 2026
Price per a person from
$507
KLM
DEPARTURE
MAD - BRU
Sun. Oct 11, 2026
Price per a person from
$623
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