Flights from Orlando to San Francisco

Flights

All filters Price Stops Airlines Time Alliances

Cheap one-way flights

If you're planning to travel one-way to San Francisco, find the best flight deals available here.
Delta Air Lines
DEPARTURE
MCO - SFO
Sun. Nov 8, 2026
Price per a person from
$227
American Airlines
DEPARTURE
MCO - SFO
Sun. Nov 8, 2026
Price per a person from
$307
American Airlines
DEPARTURE
MCO - SFO
Tue. Nov 10, 2026
Price per a person from
$307
American Airlines
DEPARTURE
MCO - SFO
Sun. Nov 8, 2026
Price per a person from
$403
American Airlines
DEPARTURE
MCO - SFO
Tue. Nov 10, 2026
Price per a person from
$741
  1. Despegar
  2. Flights
  3. Flights to North America
  4. Flights to United States of America
  5. Flights to San Francisco
  6. Flights from Orlando to San Francisco
$
Subscribe to these exclusive deals
Please, enter a valid email address
You will receive promotional emails from Despegar. For more information, see (the) privacy policies.
Subscribe to these exclusive deals
Recibí de primera mano nuestras ofertas y beneficios exclusivos.
I want to receive them!
Personalized price alerts News and offers Not-to-be-missed events View privacy policy

Tenemos un nuevo teléfono de atención para Posventa. El número que ves, ya está actualizado.

Browse on the site of:
Iata

Despegar is present on United States of America, Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Puerto Rico, Dominican Republic, Uruguay

1999-2026, Despegar.com, Inc . All rights reserved.
Find out what's new
Receive first-hand our exclusive offers and benefits.
See more