Flights from Santiago to Medellin

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Cheap one-way flights

If you're planning to travel one-way to Medellin, find the best flight deals available here.
Copa Airlines
DEPARTURE
SCL - MDE
Fri. Dec 18, 2026
Price per a person from
$342
LATAM
DEPARTURE
SCL - MDE
Fri. Dec 18, 2026
Price per a person from
$519
Avianca
DEPARTURE
SCL - MDE
Fri. Dec 18, 2026
Price per a person from
$655
Aerolíneas Argentinas
DEPARTURE
SCL - MDE
Fri. Dec 18, 2026
Price per a person from
$974
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