Flights from San Francisco to Santiago

Flights

All filters Price Stops Baggage Airlines Time Alliances Stay

Cheapest flights

American Airlines
  • Stops
DEPARTURE
SFO - SCL
Fri. Jul 9, 2027
RETURN
SCL - SFO
Tue. Jul 20, 2027
Price per a person from
$1,049
LATAM
  • Stops
DEPARTURE
SFO - SCL
Fri. Jul 9, 2027
RETURN
SCL - SFO
Tue. Jul 20, 2027
Price per a person from
$1,214
Copa Airlines
  • Stops
DEPARTURE
SFO - SCL
Fri. Jul 9, 2027
RETURN
SCL - SFO
Tue. Jul 20, 2027
Price per a person from
$1,583
Avianca
  • Stops
DEPARTURE
SFO - SCL
Fri. Jul 9, 2027
RETURN
SCL - SFO
Tue. Jul 20, 2027
Price per a person from
$1,775
Delta Air Lines
  • Stops
DEPARTURE
SFO - SCL
Fri. Jul 9, 2027
RETURN
SCL - SFO
Tue. Jul 20, 2027
Price per a person from
$1,972

Cheap one-way flights

If you're planning to travel one-way to Santiago, find the best flight deals available here.
American Airlines
DEPARTURE
SFO - SCL
Fri. Jul 9, 2027
Price per a person from
$679
Delta Air Lines
DEPARTURE
SFO - SCL
Tue. Dec 15, 2026
Price per a person from
$883
LATAM
DEPARTURE
SFO - SCL
Tue. Dec 15, 2026
Price per a person from
$1,046
American Airlines
DEPARTURE
SFO - SCL
Tue. Dec 15, 2026
Price per a person from
$923
DEPARTURE
SFO - SCL
Tue. Dec 15, 2026
Price per a person from
$1,354
Air Canada
DEPARTURE
SFO - SCL
Tue. Dec 15, 2026
Price per a person from
$4,251
  1. Despegar
  2. Flights
  3. Flights to South America
  4. Flights to Chile
  5. Flights to Santiago
  6. Flights from San Francisco to Santiago
$
Subscribe to these exclusive deals
Please, enter a valid email address
You will receive promotional emails from Despegar. For more information, see (the) privacy policies.
Subscribe to these exclusive deals
Recibí de primera mano nuestras ofertas y beneficios exclusivos.
I want to receive them!
Personalized price alerts News and offers Not-to-be-missed events View privacy policy

Tenemos un nuevo teléfono de atención para Posventa. El número que ves, ya está actualizado.

Browse on the site of:
Iata

Despegar is present on United States of America, Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Puerto Rico, Dominican Republic, Uruguay

1999-2026, Despegar.com, Inc . All rights reserved.
Find out what's new
Receive first-hand our exclusive offers and benefits.
See more